Thermo Fisher Scientific TAP2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL
• Publications: -

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

The membrane-associated protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).

This protein belongs to the MDR/TAP subfamily, which is involved in multidrug resistance. The TAP2 gene is located 7 kb telomeric to ABCB2 and is involved in antigen presentation. TAP2 forms a heterodimer with ABCB2 to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing produces two isoforms differing in peptide selectivity and MHC class I surface expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.