Thermo Fisher Scientific TAB1 Polyclonal Antibody

Thermo Fisher Scientific TAB1 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 0.1–0.5 µg/mL
Publications: - [References not available]

Product Specifications

Product Specific Information

The synthetic peptide sequence is 304–321aa, QANQEIAAMIDTEFAKQT.
Add 0.2 mL of distilled water to reconstitute; this will yield a concentration of 500 µg/mL.

Target Information

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of MAP3K7/TAK1, mediating intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for TAK1 binding and activation, while the N-terminal portion acts as a dominant-negative inhibitor of TGF beta. TAB1 can also interact with and activate MAPK14/p38alpha, providing an alternative activation pathway that contributes to MAPK14 biological responses.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.