Thermo Fisher Scientific TAB1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

• Synthetic peptide sequence: 78–108aa, NFVAQRLSAELLLGQLNAEHAEADVRRVLLQ
• Add 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminal portion can act as a dominant-negative inhibitor of TGF beta. TAB1 also interacts with and activates MAPK14/p38alpha, providing an alternative activation pathway contributing to MAPK14 biological responses to various stimuli.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.