Thermo Fisher Scientific TAB1 Polyclonal Antibody
TAB1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot에 최적화되어 있으며, 인간 TAB1 N-말단 서열 기반 합성 펩타이드로 면역화됨. Lyophilized 형태로 제공되며, 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a sequence at the N-terminus of human TAB1 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2747206 |
Product Specific Information
- Synthetic peptide sequence: 78–108aa, NFVAQRLSAELLLGQLNAEHAEADVRRVLLQ
- Add 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminal portion can act as a dominant-negative inhibitor of TGF beta. TAB1 also interacts with and activates MAPK14/p38alpha, providing an alternative activation pathway contributing to MAPK14 biological responses to various stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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