Thermo Fisher Scientific Factor VIII Monoclonal Antibody (F8 2.2.9)

Applications

Western Blot (WB)

• Tested Dilution: 1–10 µg/mL

ELISA

• Tested Dilution: 1–10 µg/mL

Product Specifications

Product Specific Information

• MA1-10587 detects the full length of Factor VIII from human samples.
• This antibody does not cross-react with von Willebrand factor.
• Successfully used in ELISA and Western blot applications.
• Immunogen: Purified human Factor VIII.

Target Information

The Factor VIII gene encodes a coagulation factor that participates in the intrinsic pathway of blood coagulation.
Factor VIII acts as a cofactor for factor IXa, which converts factor X to the activated form Xa in the presence of Ca²⁺ and phospholipids.
Two alternatively spliced transcripts exist:

1. Isoform a: large glycoprotein that circulates in plasma and associates with von Willebrand factor.
2. Isoform b: smaller protein primarily consisting of the phospholipid binding domain essential for coagulant activity.

Defects in this gene result in hemophilia A, a common recessive X-linked coagulation disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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