Thermo Fisher Scientific Factor VIII Monoclonal Antibody (F8-2.2.32)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-10 µg/mL

-

ELISA (ELISA)

1-10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

F8-2.2.32

Immunogen

Purified human Factor VIII. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Factor VIII,uniProtId:P00451-1,ncbiNodeId:9606,antigenRange:1-2351,antigenLength:2351,antigenImageFileName:MA1-10588_Factor_VIII_P00451-1_House_mouse.svg,antigenImageFileNamePDP:MA1-10588_Factor_VIII_P00451-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1074336

Product Specific Information

MA1-10588 detects full-length human Factor VIII. This antibody does not cross-react with von Willebrand factor.

MA1-10588 has been successfully used in ELISA and Western blot applications.

The MA1-10588 immunogen is purified human Factor VIII.

Target Information

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.