Thermo Fisher Scientific MeCP2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This affinity-purified antibody is directed against human MeCP2. A BLAST analysis suggests cross-reactivity with mouse, rat, and Macaca fascicularis based on 100% sequence homology.

Target Information

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that contain a methyl-CpG binding domain. MECP2 binds specifically to methylated DNA, playing a key role in mammalian development and transcriptional repression of methylated gene promoters.
Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. It is dispensable in stem cells but essential for embryonic development. Mutations in the MECP2 gene cause most cases of Rett syndrome, a progressive neurological developmental disorder and a major cause of mental retardation in females.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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