Thermo Fisher Scientific SNAI1 Polyclonal Antibody
SNAI1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. WB, IHC, ICC, ELISA, IP 등 다양한 응용에 사용 가능하며, 고순도 Affinity chromatography로 정제된 액상 제품입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific SNAI1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:300 |
| Immunocytochemistry (ICC/IF) | 15 µg/mL |
| ELISA | 1:10,000–1:50,000 |
| Immunoprecipitation (IP) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an internal portion of human SNAI1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.03 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This affinity purified antibody is directed against human SNAI1. A BLAST analysis suggests cross-reactivity with human and mouse based on 100% sequence homology with the immunizing peptide.
Target Information
Zinc finger protein SNAI1 (SNAIL) is a transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and contributes to mesoderm and neural crest formation. SNAI1 plays a key role in tumor invasion through E-cadherin downregulation and induction of epithelial-mesenchymal transition (EMT). In breast cancer, expression of SNAI1 and/or SNAI2 (Slug) is associated with E-cadherin repression, metastasis, tumor recurrence, and poor prognosis. Snail 1 protein in stroma may serve as a prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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