Thermo Fisher Scientific AIPL1 Polyclonal Antibody
AIPL1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 고순도와 높은 특이성을 제공. 인간 시료에 반응하며, 시각 수용체 발달 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human AIPL1 (1–384 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720671 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1) is a tetratricopeptide repeat protein associated with Leber congenital amaurosis (LCA), an autosomal recessive disorder affecting photoreceptor development. AIPL1 shares high homology with ARA9, a co-chaperone involved in HSP90-mediated nuclear translocation of the aryl hydrocarbon receptor. It forms part of a chaperone complex interacting with Hsp90 and Hsp70, and associates with NUB1, a cell cycle regulator. AIPL1 cooperates with Hsp70 to suppress NUB1 inclusion formation, essential for normal photoreceptor maturation. Mutations disrupting these interactions can lead to LCA. At least three isoforms of AIPL1 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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