Thermo Fisher Scientific SKAP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and act as substrates for p59Fyn in resting T cells.
SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif with adjacent arginine and lysine residues followed by tandem tyrosines (RKxxYxxY). SKAP55-R has a similar structure and includes a coiled-coil N-terminal domain.
SKAP55 associates with SLAP-130, another component of the Fyn complex, which regulates signaling events initiated by lymphocyte antigen receptors leading to T-cell activation.
The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.