Thermo Fisher Scientific PYGL Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

This gene encodes a homodimeric enzyme that catalyzes the cleavage of α-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. The enzyme is activated by phosphorylation at serine residue 15, switching from phosphorylase B to phosphorylase A. Its activity is regulated by allosteric effectors and hormonal control mechanisms.

Humans express three glycogen phosphorylase isozymes primarily in liver, brain, and muscle. The liver isozyme maintains systemic glucose levels, while the brain and muscle isozymes serve local energy demands. Mutations in the liver glycogen phosphorylase gene cause glycogen storage disease type VI (Hers disease), characterized by inhibited glycogen-to-glucose conversion, moderate hypoglycemia, mild ketosis, growth retardation, and hepatomegaly. Alternative splicing produces multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.