Thermo Fisher Scientific Spectrin beta-3 Recombinant Superclonal Antibody (14HCLC)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Cat, and Rat.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They combine multiple recombinant monoclonal antibodies, delivering both the sensitivity of polyclonal antibodies and the specificity of monoclonal antibodies with consistent recombinant production.
While functionally similar to polyclonal antibodies—recognizing multiple epitopes and providing higher detection sensitivity for low-abundance targets—Superclonal™ antibodies have a defined mixture of light and heavy chains, ensuring reproducibility across lots.
Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. Physical product and performance remain unchanged.

Target Information

Spectrins are principal components of the cell membrane-cytoskeleton, composed of two alpha and two beta subunits.
The SPTBN2 gene encodes spectrin beta non-erythrocytic 2 (beta-III spectrin), distinct from SPTBN1 (beta-II spectrin).
SPTBN2 regulates glutamate signaling by stabilizing the EAAT4 transporter at the plasma membrane.
Mutations in SPTBN2 cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.