Thermo Fisher Scientific Nephrin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: Mouse kidney, mouse brain, rat brain
• Cellular Location: Cell membrane, Single-pass type I membrane protein

Immunogen Sequence:
LGDSGLADKG TQLPITTPGL HQPSGEPEDQ LPTEPPSGPS GLPLLPVLFA LGGLLLLSNA SCVGGVLWQR RLRRLAEGIS EKTEAGSEED RVRNEYEESQ WTGERDTQSS TVSTTEAEPY YRSLRDFSPQ LPPTQEEVSY SRGFTGEDED MAFPGHLYDE VERTYPPSGA WGPLYDEVQM GPWDLHWPED TYQDPRGIYD QVAGDLDTLE PDSLPFELRG HLV

Target Information

Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2.

Nephrin, a recently identified protein, is a major component of the slit diaphragm in podocyte foot processes and plays a crucial role in maintaining the glomerular filtration barrier. Mutations in the gene for Nephrin are associated with congenital nephrosis. Nephrin also participates in anti-apoptotic activity related to VEGF signaling and may anchor the podocyte slit diaphragm to the actin cytoskeleton.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.