Thermo Fisher Scientific Nephrin Polyclonal Antibody
Nephrin 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 ELISA에 적합합니다. Human, Mouse, Rat 반응성이 있으며, 세포막 단일 통과형 단백질 검출에 유용합니다. Affinity Chromatography로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 2 publications |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1019–1241 of human NPHS1 (NP_0046371) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.68 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806323 |
Product Specific Information
- Positive Samples: Mouse kidney, mouse brain, rat brain
- Cellular Location: Cell membrane, Single-pass type I membrane protein
Immunogen Sequence:
LGDSGLADKG TQLPITTPGL HQPSGEPEDQ LPTEPPSGPS GLPLLPVLFA LGGLLLLSNA SCVGGVLWQR RLRRLAEGIS EKTEAGSEED RVRNEYEESQ WTGERDTQSS TVSTTEAEPY YRSLRDFSPQ LPPTQEEVSY SRGFTGEDED MAFPGHLYDE VERTYPPSGA WGPLYDEVQM GPWDLHWPED TYQDPRGIYD QVAGDLDTLE PDSLPFELRG HLV
Target Information
Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2.
Nephrin, a recently identified protein, is a major component of the slit diaphragm in podocyte foot processes and plays a crucial role in maintaining the glomerular filtration barrier. Mutations in the gene for Nephrin are associated with congenital nephrosis. Nephrin also participates in anti-apoptotic activity related to VEGF signaling and may anchor the podocyte slit diaphragm to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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