Thermo Fisher Scientific FGF2 Monoclonal Antibody (OTI3D9), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

FGF2 (fibroblast growth factor basic, FGFb) is a member of the FGF family that interacts with high-affinity transmembrane receptors, influencing cell proliferation and neovascularization.
It exists in five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is cytosolic and acts via cell surface receptors, while the 22, 22.5, 24, and 34 kDa isoforms are nuclear and may signal independently of transmembrane receptors.

In humans, the gene is located on chromosome 4q. FGF2 is involved in limb and nervous system development, wound healing, and tumor growth.
Its mRNA contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG initiation codons, producing isoforms with distinct functions.
CUG-initiated isoforms are nuclear (intracrine signaling), while AUG-initiated forms are cytosolic (paracrine/autocrine signaling).
Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.