Thermo Fisher Scientific Stat4 Monoclonal Antibody (OTI2A2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

STAT4 (Signal Transducer and Activator of Transcription 4) is a member of the STAT protein family. It is phosphorylated by Jak1 or Jak2 and forms homo- or heterodimers with other STAT proteins. Activated STAT4 binds to the IFN-γ activated site (GAS) and requires serine phosphorylation for maximal transcriptional activity.

STAT4 expression is mainly found in the thymus, spleen, and testis. It is activated by interleukin-12 (IL-12), which is essential for T-cell independent induction of IFN-γ and development of Th1 responses critical for defense against intracellular pathogens. STAT4-deficient mice show impaired IL-12-mediated Th1 development and enhanced Th2 cell differentiation. Additionally, IFN-α/β-mediated activation of STAT4 is required for IFN-γ production during viral infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.