Thermo Fisher Scientific DISC1 Polyclonal Antibody, DyLight 488
DyLight 488 형광 표지 DISC1 폴리클로날 항체로, 인간·마우스·랫트 시료에서 DISC1 단백질 검출에 적합. IHC 및 ICC/IF 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 신경세포 DISC1 연구용으로 최적화.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 2.5–5 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an internal region (residues 400–500) of rat DISC1 protein |
| Conjugate | DyLight™ 488 |
| Excitation / Emission Max | 492 / 519 nm |
| Form | Liquid |
| Concentration | 0.70 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 50 mM sodium borate |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154569 |
Product Specific Information
- Theoretical molecular weight of DISC1: ~90 kDa
- Alternative splicing forms may appear at ~75 and 100 kDa
- Suggested positive control: human brain sections (neurons and glia)
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein interacting with various centrosomal and cytoskeletal proteins, playing key roles in neuronal migration, neurite architecture, and intracellular transport.
It is expressed in regions such as the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus.
Loss of DISC1 function is linked to structural brain differences and schizophrenia-associated chromosomal translocations.
DISC1 interacts with proteins like MIPT3, MAP1A, NUDEL, alpha-actinin 2, beta 4-spectrin, ATF-4, and ATF-5, implicating it in dendritic development and synapse formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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