Thermo Fisher Scientific Phospho-ATM (Ser1987) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of ATM only when phosphorylated at Ser1987.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.

The ATM gene encodes a protein within the phosphoinositide 3-kinase (PI3K) superfamily.
ATM phosphorylates proteins rather than lipids and targets multiple downstream regulators of the cell cycle, including P53, Mdm2, BRCA1, and SMC1.
ATM is essential for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens.

The C-terminal region of ATM shows homology to catalytic domains of PI3 kinases.
Upon exposure to ionizing radiation, ATM becomes autophosphorylated and activated, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM also participates in apoptosis signaling through interactions with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.