Thermo Fisher Scientific Phospho-ATM (Ser794) Polyclonal Antibody

Thermo Fisher Scientific Phospho-ATM (Ser794) Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of ATM only when phosphorylated at Ser794.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein within the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and has many downstream targets that act as cell-cycle regulators, including P53, Mdm2, BRCA1, and SMC1.
ATM is responsible for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. The C-terminal region of ATM shows extensive homology to the catalytic domains of PI3 kinases.
Upon exposure to ionizing radiation, ATM becomes autophosphorylated and upregulated. AT cells are hypersensitive to ionizing radiation, show impaired inhibition of DNA synthesis, and delayed p53 induction. DNA damage activates ATM kinase, triggering a cascade of reactions regulating cell cycle, apoptosis, and DNA damage repair.
ATM has been linked to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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