Thermo Fisher Scientific Spastin Recombinant Rabbit Monoclonal Antibody (RM346)
Recombinant rabbit monoclonal antibody targeting human Spastin protein. Validated for WB and IHC applications with high specificity and lot-to-lot consistency. Produced in HEK293 cells, purified via Protein A, and supplied in PBS with BSA and glycerol ...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM346 |
| Immunogen | A peptide corresponding to the N-terminus of human Spastin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2744995 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
The Spastin gene encodes a member of the AAA (ATPases Associated with a variety of cellular Activities) protein family. These proteins share an ATPase domain and are involved in diverse cellular processes such as membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis.
The encoded ATPase may participate in nuclear protein complex assembly or function. Two transcript variants encoding distinct isoforms have been identified, along with other splice variants of undetermined full-length sequences. Mutations in this gene cause autosomal dominant spastic paraplegia type 4, the most common form of this disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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