Thermo Fisher Scientific DIABLO Recombinant Rabbit Monoclonal Antibody (RM271)
Recombinant rabbit monoclonal antibody (RM271) targeting human DIABLO/Smac. Validated for WB and IHC-P applications. Provides high specificity, sensitivity, and lot-to-lot consistency. Supplied in liquid form with Protein A purification for reliable re...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM271 |
| Immunogen | A peptide corresponding to the C-terminus of human Smac (Diablo homolog, mitochondrial) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2744994 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
DIABLO (Smac) is a mitochondrial protein involved in the activation of apoptosis by neutralizing members of the IAP (Inhibitor of Apoptosis Proteins) family. During apoptotic signaling, Smac exits the mitochondria and enters the cytosol, promoting cell death pathways.
Mitochondrial-mediated apoptosis is essential for development and tissue homeostasis, and its dysregulation is linked to various cancers. Smac/DIABLO also plays a role in sensitizing cancer cells to immune- or drug-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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