Thermo Fisher Scientific Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (Chk1S317-F10)
Phospho-Chk1 (Ser317)을 인식하는 재조합 토끼 단일클론 항체로, 높은 특이성과 재현성을 제공합니다. Flow Cytometry 등 다양한 응용에 적합하며, lot 간 일관성이 우수합니다. 연구용으로 DNA 손상 반응 연구 및 암 관련 신호전달 분석에 활용됩니다.
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Applications
- Flow Cytometry (Flow): 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S317-F10 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2744999 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Key advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the large rabbit immune repertoire
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. It acts as a key mediator in the DNA damage-induced checkpoint network and is evolutionarily conserved to ensure genomic integrity under genotoxic stress.
Inhibition of CHK1 can lead to mitotic catastrophe and apoptosis in p53-deficient cancer cells, making CHK1 an attractive therapeutic target in oncology research.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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