Thermo Fisher Scientific Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (Chk1S317-G1), PE
PE 형광표지된 Phospho-Chk1 (Ser317) 재조합 토끼 단클론 항체로, 인간 및 마우스 시료에 반응합니다. 높은 특이성과 재현성을 제공하며, Flow Cytometry에 적합합니다. DNA 손상 체크포인트 연구용으로 추천됩니다.
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Thermo Fisher Scientific Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (Chk1S317-G1), PE
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S317-G1 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2744998 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase that prevents replication when DNA integrity is compromised. It is a key mediator in the DNA damage-induced checkpoint network and ensures genomic integrity under genotoxic stress.
Inhibition of CHK1 can lead to mitotic catastrophe and apoptosis in p53-deficient cancer cells, making CHK1 an attractive therapeutic target for cancer treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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