ELK Biotechnology β-1,4-Gal-T1 rabbit pAb

제품명

β-1,4-Gal-T1 rabbit pAb

기본 정보

세포 내 위치 (Cellular Localization)

• Isoform Long: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  Cell membrane; Single-pass type II membrane protein.
  Cell surface; Cell projection, filopodium.
  Found in trans cisternae of Golgi but mainly localized at the plasma membrane (PubMed:1714903).
  B4GALT1 cell surface expression is regulated by UBE2Q1 (By similarity).

• Isoform Short: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  Found in trans cisternae of Golgi.

• Processed β-1,4-galactosyltransferase 1: Secreted; Soluble form found in body fluids.

Background

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that have exclusive specificity for the donor substrate UDP-galactose. All transfer galactose in a β1,4 linkage to acceptor sugars such as GlcNAc, Glc, and Xyl.
Each beta4GalT has a distinct role in biosynthesis of glycoconjugates and saccharide structures. As type II membrane proteins, they possess an N-terminal hydrophobic signal sequence directing them to the Golgi apparatus, which remains uncleaved and functions as a transmembrane anchor.
By sequence similarity, beta4GalTs form four groups:

• beta4GalT1 and beta4GalT2
• beta4GalT3 and beta4GalT4
• beta4GalT5 and beta4GalT6
• beta4GalT7

This gene is unique among beta4GalT genes because it encodes an enzyme participating in both glycoconjugate and lacto biosynthesis.