ELK Biotechnology Akt1 (phospho Thr72) rabbit pAb
Akt1 (phospho Thr72) rabbit pAb는 인간, 마우스, 랫트에서 반응하는 다클론 항체로 WB, IHC, IF, ELISA에 사용 가능합니다. Thr72 인산화 부위 기반으로 제작되었으며, 세포질과 핵에서 발현된 Akt1 검출에 적합합니다. -20°C 보관 시 1년 안정합니다.
- 카탈로그번호
- ES5160-xxxxx (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Akt1 (phospho Thr72) rabbit pAb
제품명
Akt1 (phospho Thr72) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Akt around the phosphorylation site of Thr72 (AA range: 38–87) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kDa |
| Gene ID (Human) | 207 |
| Human Swiss-Prot No. | P31749 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Nucleus, Cell membrane. Translocates to the nucleus after activation by ILK1. Localization to the membrane is enhanced by phosphorylation on Tyr-176 by TNK2, leading to subsequent phosphorylations on Thr-308 and Ser-473 for activation. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). |
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved fibroblasts. AKT1 and AKT2 are activated by platelet-derived growth factor through a phosphatidylinositol 3-kinase-dependent mechanism.
In the developing nervous system, AKT1 acts as a critical mediator of growth factor-induced neuronal survival. It suppresses apoptosis by phosphorylating and inactivating apoptotic components in a transcription-independent manner.
Mutations in this gene are associated with Proteus syndrome, and multiple alternatively spliced transcript variants have been identified (RefSeq, Jul 2011).
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.