ELK Biotechnology NARF rabbit pAb

제품명

NARF rabbit pAb

대체 명칭

NARF; Nuclear prelamin A recognition factor; Iron-only hydrogenase-like protein 2; IOP2

적용 분야

• WB
• ELISA
• IHC

권장 희석 배율

• WB: 1:500–2000
• IHC-p: 1:50–300
• ELISA: 1:2000–20000

면역원

The antiserum was produced against synthesized peptide derived from human NARF.
AA range: 262–311

보관 조건

• 종: Rabbit
• 온도: -20°C / 1 year

항체 특성

배경 설명

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina.