Product name: |
Mnk2 rabbit pAb |
Alternative Names: |
MKNK2; GPRK7; MNK2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2 |
Applications: |
WB;ELISA;IHC |
Recommended Dilutions: |
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
Immunogen: |
Synthesized peptide derived from the Internal region of human Mnk2. |
Storage: |
Rabbit |
Storage: |
-20°C/1 year |
Clonality: |
Polyclonal |
Isotype: |
IgG |
Concentration: |
1 mg/ml |
Observed Band: |
51kD |
GeneID(Human): |
2872 |
Human Swiss-Prot No: |
Q9HBH9 |
Cellular localization: |
[Isoform 2]: Nucleus, PML body.; [Isoform 1]: Cytoplasm. |
Background: |
MAP kinase interacting serine/threonine kinase 2(MKNK2) Homo sapiens This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. |
Species Reactivity: |
Human;Mouse;Rat |