Thermo Fisher Scientific MFN2 Monoclonal Antibody (N153/5), PE

Applications and Tested Dilution

Product Specifications

Available Formats

• Unconjugated (MA5-27647)
• APC (MA5-45669)
• FITC (MA5-45670)
• PerCP (MA5-45671)
• Request custom conjugation

Product Specific Information

• Rat: 97% identity (226/231 amino acids identical)
• Human: 92% identity (214/231 amino acids identical)
• ~55% identity with Mitofusin-1
• Detects approximately 90 kDa
• No cross-reactivity against Mitofusin-1
• 1 µg/mL of MA5-45672 was sufficient for detection of Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody
• This antibody was formerly sold as clone S153-5

Target Information

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. It regulates vascular smooth muscle cell proliferation and may play a role in obesity-related pathophysiology. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2 and hereditary motor and sensory neuropathy VI, both disorders of the peripheral nervous system. Defects have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지