Thermo Fisher Scientific MFN2 Monoclonal Antibody (N153/5), PerCP
MFN2 단일클론 항체(N153/5), PerCP 형으로 인간, 마우스, 랫트 시료에 반응. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 단백질 G 정제, 보존제 없음, 4°C 보관. 미토콘드리아 융합 및 신경계 질환 연구용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N153/5 |
| Immunogen | Fusion protein amino acids 370–600 (cytoplasmic N-terminus) of mouse Mitofusin-2 |
| Conjugate | PerCP |
| Excitation/Emission Max | 482/675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932125 |
Additional Formats
Product Specific Information
- Rat: 97% identity (226/231 amino acids identical)
- Human: 92% identity (214/231 amino acids identical)
- ~55% identity with Mitofusin-1
- 1 µg/mL of MA5-45671 detects Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP as secondary antibody
- Detects approximately 90 kDa
- No cross-reactivity against Mitofusin-1
- Formerly sold as clone S153-5
Target Information
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. It regulates vascular smooth muscle cell proliferation and may play a role in obesity pathophysiology.
Mutations cause Charcot-Marie-Tooth disease type 2A2 and hereditary motor and sensory neuropathy VI, both peripheral nervous system disorders. Defects are also associated with early-onset stroke.
Two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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