Thermo Fisher Scientific SHANK1/SHANK3 Monoclonal Antibody (N367/51), APC
SHANK1/SHANK3 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체(APC 결합형). 인간, 마우스, 랫에서 반응하며 WB, IHC, ICC에 사용 가능. 단백질 G 정제, 보존제 없음, 4°C 보관.
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Thermo Fisher Scientific SHANK1/SHANK3 Monoclonal Antibody (N367/51), APC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N367/51 |
| Immunogen | Fusion protein amino acids 538–626 (SH3 domain) of rat SHANK3 |
| Conjugate | APC |
| Excitation/Emission Max | 651/660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932127 |
Available Formats
- FITC (MA5-45674)
- PE (MA5-45676)
- PerCP (MA5-45675)
- Custom conjugation available upon request
Product Specific Information
- Mouse: 100% identity (89/89 amino acids identical)
- Human: 97% identity (87/89 amino acids identical)
- ~70% identity with SHANK1 and SHANK2
- Detects approximately 190 kDa
- Cross-reacts with SHANK1, does not cross-react with SHANK2
- 1 µg/mL sufficient for detection of SHANK1/SHANK3 in 20 µg rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP
- Formerly sold as clone S367-51
Target Information
Major scaffold postsynaptic density protein interacting with multiple proteins and complexes to orchestrate dendritic spine and synapse formation, maturation, and maintenance.
Interconnects NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, and links to the actin-based cytoskeleton.
Regulates actin dynamics, neuronal growth cone motility, and NMDA receptor signaling.
Modulates GRIA1 exocytosis and GRM5/MGLUR5 signaling to control synaptic transmission and plasticity.
May play a role in early synapse formation and maturation, influenced by IGF1.
{PubMed:21606927, 21795692, 23100419, 23897824, 24089484}
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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