Thermo Fisher Scientific ASAH1 Polyclonal Antibody
Human ASAH1 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 안정적. 암 연구 및 리소좀 대사 관련 연구에 적합.
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Thermo Fisher Scientific ASAH1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ASAH1 (Product #RP-88819) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2638263 |
Product Specific Information
Immunogen sequence:
ENSTSYEEAK NLLTKTKILA PAYFILGGNQ SGEGCVITRD RKESLDVYEL DAKQGRWYVV QTNYDRWKHP FFLDDRRTPA KMCLNRTSQE NISFETMYDV LSTKPVLNKL TVYTTLIDVT KGQF
Highest antigen sequence identity to orthologs:
- Mouse: 82%
- Rat: 86%
Target Information
ASAH1 encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. The processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid.
This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in ASAH1 are associated with lysosomal storage disorder Farber lipogranulomatosis and neuromuscular disorder spinal muscular atrophy with progressive myoclonic epilepsy.
Related Pathways:
- Innate Immune System
- Sphingolipid Metabolism
Associated Diseases:
- Farber Lipogranulomatosis
- Spinal Muscular Atrophy with Progressive Myoclonic Epilepsy
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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