Thermo Fisher Scientific ASAH1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

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Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

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Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ASAH1. Recombinant protein control fragment (Product #RP-88819). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ASAH1,uniProtId:Q13510-1,ncbiNodeId:9606,antigenRange:258-381,antigenLength:395,antigenImageFileName:PA5-52150_ASAH1_Q13510-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52150_ASAH1_Q13510-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638263

Product Specific Information

Immunogen sequence: ENSTSYEEAK NLLTKTKILA PAYFILGGNQ SGEGCVITRD RKESLDVYEL DAKQGRWYVV QTNYDRWKHP FFLDDRRTPA KMCLNRTSQE NISFETMYDV LSTKPVLNKL TVYTTLIDVT KGQF

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 86%.

Target Information

ASAH1 encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. The processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene have been linked to the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. The related pathways include Innate Immune System and Sphingolipid metabolism. Diseases associated with ASAH1 include Farber Lipogranulomatosis and Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.