Thermo Fisher Scientific KANK1 Polyclonal Antibody
인간 KANK1 단백질을 인식하는 Rabbit Polyclonal 항체로 면역조직화학(IHC-P)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공됩니다. 세포골격 조절 및 종양 억제 연구에 활용 가능합니다.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KANK1. Recombinant protein control fragment (Product #RP-101071) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642867 |
Product Specific Information
Immunogen sequence:
INVCGVRKRS YSAGNASQLE QLSRARRSGG ELYIDYEEEE METVEQSTQR IKEFRQLTAD MQALEQKIQD SSCEASSELR ENGECRSVAV GAEENMNDIV VYHRGSRSCK DAAVGTLVEM RNCGVSVTEA MLGVMTEADK EIE
- Highest antigen sequence identity to orthologs:
- Mouse: 80%
- Rat: 81%
Target Information
Ankyrins are membrane adaptor molecules that play important roles in controlling cytoskeleton formation by regulating actin polymerization.
KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein containing at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution.
KANK1 is ubiquitously expressed and localizes to the cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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