Thermo Fisher Scientific Gemin 3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Gemin 3. Recombinant protein control fragment (Product #RP-102050). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Gemin 3,uniProtId:Q9UHI6-1,ncbiNodeId:9606,antigenRange:352-492,antigenLength:824,antigenImageFileName:PA5-52157_Gemin_3_Q9UHI6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52157_Gemin_3_Q9UHI6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641951

Product Specific Information

Immunogen sequence: MAKLKHFHCR VLISTDLTSR GIDAEKVNLV VNLDVPLDWE TYMHRIGRAG RFGTLGLTVT YCCRGEEENM MMRIAQKCNI NLLPLPDPIP SGLMEECVDW DVEVKAAVHT YGIASVPNQP LKKQIQKIER TLQIQKAHGD H

Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 84%.

Target Information

Gemin 3 is a member of the DEAD box protein family which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. DEAD box proteins such as Gemin 3 are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of DEAD box family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Gemin 3 has an ATPase activity and a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 protein dysfunction include spinal muscular dystrophy and muscular atrophy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.