Thermo Fisher Scientific FMNL2 Polyclonal Antibody
FMNL2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관됩니다. 인간 시료에 반응하며, 세포 극성 및 형태 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FMNL2. Recombinant protein control fragment (Product #RP-88596). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641681 |
Product Specific Information
Immunogen sequence:
ERVEELEENI SHLSEKLQDT ENEAMSKIVE LEKQLMQRNK ELDVVREIYK DANTQVHTLR KMVKEKEEAI QRQSTLEKKI HELEKQGTIK IQKKGDGDIA ILPVVASGTL SMGSEVVAGN SVGP
Antigen sequence identity:
- Mouse: 94%
- Rat: 95%
Target Information
Formin-like protein 2 (FMNL2) is a cytoplasmic phosphoprotein belonging to the formin homology domain-containing protein family. It includes DAD (diaphanous autoregulatory domain), FH2 (formin homology 2), and GBD/FH3 (Rho GTPase-binding/formin homology 3) domains.
Although the exact function of FMNL2 is not fully understood, it is suggested to play a role in the Wnt signaling pathway. Formin-related proteins are involved in morphogenesis, cytokinesis, and cell polarity. Several alternatively spliced transcript variants have been described but their full-length nature remains undetermined.
FMNL2 has been associated with diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma. It may be implicated in polarity control, invasion, migration, or metastasis through actin filament nucleation and may be regulated by Rho family GTPase.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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