Thermo Fisher Scientific FMNL2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FMNL2. Recombinant protein control fragment (Product #RP-88596). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FMNL2,uniProtId:Q96PY5-1,ncbiNodeId:9606,antigenRange:393-516,antigenLength:1086,antigenImageFileName:PA5-52148_FMNL2_Q96PY5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52148_FMNL2_Q96PY5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641681

Product Specific Information

Immunogen sequence: ERVEELEENI SHLSEKLQDT ENEAMSKIVE LEKQLMQRNK ELDVVREIYK DANTQVHTLR KMVKEKEEAI QRQSTLEKKI HELEKQGTIK IQKKGDGDIA ILPVVASGTL SMGSEVVAGN SVGP

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

Target Information

Formin-like protein 2 is a cytoplasmic phosphoprotein belonging to the formin homology domain containing protein family and has a DAD (diaphanous autoregulatory domain), FH2 (formin homology 2) domain, and GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. The exact function of FMNL2 is yet to be known but reports suggest that it may have a role in the Wnt signaling pathway. Formin-related proteins are also known to play an important role in morphogenesis, cytokinesis and cell polarity. Several alternatively spliced transcript variants have been described but their full-length nature is not yet determined. It is also known to be associated with a diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma. FMNL2 might be implicated in polarity control, invasion, migration or metastasis through actin filament nucleation and may be regulated by Rho family GTPase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.