Thermo Fisher Scientific SQSTM1/p62 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This affinity-purified antibody is directed against human SQSTM1/p62.
BLAST analysis suggests cross-reactivity with human, mouse, rat, and Pongo abelii based on 100% homology with the immunizing sequence.
Cross-reactivity with SQSTM1 from other sources has not been determined.

Target Information

The SQSTM1 gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway.
This protein acts as a scaffolding/adaptor molecule with TNF receptor-associated factor 6 to mediate NF-κB activation in response to upstream signals.
Alternatively spliced transcript variants encoding different isoforms have been identified.
Mutations in this gene are associated with sporadic and familial Paget disease of bone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.