Thermo Fisher Scientific Phospho-PTPRA (Tyr271) Polyclonal Antibody
Phospho-PTPRA (Tyr271) 폴리클로날 항체로 인산화된 PTPα를 특이적으로 검출합니다. Western blot, IHC, ICC/IF에 사용 가능하며 사람, 생쥐, 랫트 반응성을 가집니다. 고순도 정제, 액상 형태, -20°C 보관.
- 카탈로그번호
- PA5105519
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PTPRA (Accession P18433), corresponding to amino acid residues around phosphorylated Tyr271 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816947 |
Product Specific Information
This antibody detects endogenous levels of PTP alpha only when phosphorylated at Tyr271.
Target Information
Phosphorylation of receptors by protein kinases can be reversed by protein phosphatases. These enzymes regulate the dynamic balance between phosphorylated and dephosphorylated protein states, enabling cells to respond quickly to environmental stimuli. Dysregulation of this balance may lead to uncontrolled cell growth, cancer, and developmental disorders. Protein phosphatases often have broad substrate specificity, influencing multiple signaling pathways and coordinating physiological responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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