Thermo Fisher Scientific Phospho-VEGF Receptor 1 (Tyr1048) Polyclonal Antibody
VEGFR1의 Tyr1048 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 1mg/mL 농도의 액상 형태로, PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FLT1 (Accession P17948), corresponding to amino acid residues around phosphorylated Tyr1048 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816945 |
Product Specific Information
This antibody detects endogenous levels of VEGFR1 only when phosphorylated at Tyr1048.
Target Information
FLT1 (VEGFR1) is a receptor tyrosine kinase that plays a critical role in angiogenesis. Active angiogenesis is important in both pathological and physiological processes such as tumor progression, diabetic retinopathy, rheumatoid arthritis, and wound healing.
FLT1 may act as a negative regulator of embryonic angiogenesis by inhibiting excessive endothelial cell proliferation, while promoting angiogenesis and cell survival in adulthood. It exhibits high affinity for VEGFA but relatively low kinase activity, potentially functioning as a negative regulator by limiting free VEGFA availability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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