Thermo Fisher Scientific Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (9H8L15)
Tyrosine Hydroxylase를 표적하는 recombinant rabbit monoclonal antibody로, WB, IHC, ICC/IF에 사용 가능. 높은 특이성과 재현성을 제공하며 인간 및 마우스 반응성. 단백질 A 정제, 0.5 mg/mL 농도, PBS buffer에 sodium azide 포함. 연구용 전용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9H8L15 |
| Immunogen | Protein corresponding to Human TH (aa 64–269) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2609671 |
Product Specific Information
This antibody is predicted to react with Monkey and Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Improved specificity and sensitivity
- Consistent lot-to-lot performance
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters—dopamine, epinephrine, and norepinephrine.
Catecholamine synthesis is regulated by TH interaction with tetrahydrobiopterin (BH4), which binds to the catalytic domain to activate the enzyme.
Human TH has four splice variants (hTH1–hTH4) differing in regulatory domains, while sharing identical catalytic domains.
TH converts L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology.
Its role in neurotransmitter synthesis links TH to various neuropathogenic and cardiovascular diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and others.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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