Thermo Fisher Scientific Spectrin beta-3 Recombinant Rabbit Monoclonal Antibody (14H1L14)
Spectrin beta-3 단백질을 인식하는 재조합 토끼 모노클로날 항체로, Human 반응성을 확인하였으며 ICC/IF에 사용 가능. 높은 특이성과 민감도, 로트 간 일관성, 동물유래 성분 없음. 단기 4°C, 장기 -20°C 보관.
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Thermo Fisher Scientific Spectrin beta-3 Recombinant Rabbit Monoclonal Antibody (14H1L14)
Applications
- Immunocytochemistry (ICC/IF): 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 14H1L14 |
| Immunogen | Peptides corresponding to Human SPTBN2 (aa 1334–1351, 1733–1750) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2633040 |
Product Specific Information
This antibody is predicted to react with Monkey, Cat, and Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
Spectrins are principal components of a cell’s membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits.
The protein encoded by this gene (SPTBN2) is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in this gene cause a form of spinocerebellar ataxia (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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