Thermo Fisher Scientific Spectrin beta-3 Recombinant Rabbit Monoclonal Antibody (14H1L14)

Thermo Fisher Scientific Spectrin beta-3 Recombinant Rabbit Monoclonal Antibody (14H1L14)

Applications

• Immunocytochemistry (ICC/IF): 2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Cat, and Dog.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

Target Information

Spectrins are principal components of a cell’s membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits.
The protein encoded by this gene (SPTBN2) is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in this gene cause a form of spinocerebellar ataxia (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.