Thermo Fisher Scientific ABCC7 (CFTR) Polyclonal Antibody
ABCC7(CFTR) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. 합성 펩타이드(aa 650–700)로 면역화됨. 인간 시료에 반응하며, 동결건조 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 650–700 of human ABCC7 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide shares 93% identity with rat sequence.
- Specificity: ABCC7.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to abnormal chloride transport. This mutation is lethal, often through lung and liver disease. Interestingly, Salmonella typhi uses CFTR to enter intestinal epithelial cells, and ΔF508 heterozygote and homozygote mice show 86% and 100% reductions in S. typhi intestinal submucosal uptake, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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