Thermo Fisher Scientific Aggrecan Polyclonal Antibody
Thermo Fisher Scientific의 Aggrecan Polyclonal Antibody는 인간 단백질에 반응하는 토끼 폴리클로날 항체로, WB와 IHC에 적합합니다. 합성 펩타이드를 면역원으로 사용하며, cartilage matrix 연구에 활용됩니다. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장.
- 카탈로그번호
- OSA00260W-100UL
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous (PubMed) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 20–70 of human Aggrecan conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide shares 89% identity with rat and mouse sequences.
- Specificity: Aggrecan.
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene.
It is a major structural component of the extracellular matrix in cartilage and provides resistance to compression.
The human protein consists of 2316 amino acids (~250 kDa) and can exist in multiple isoforms due to alternative splicing.
Aggrecan has a bottlebrush-like structure with chondroitin sulfate and keratan sulfate chains attached to its core protein.
It contains three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Aggrecan fragments are released into synovial fluid during all stages of osteoarthritis due to cleavage by aggrecanase and MMP activity.
Antibodies BC-3 and BC-4 can detect these neo-epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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