Thermo Fisher Scientific ABCC5 (MRP5) Polyclonal Antibody
ABCC5(MRP5) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB와 IHC에 사용 가능. 합성 펩타이드(aa 500-550)를 항원으로 제작되었으며, 인간 시료에 반응. 연구용으로 안정적이고 보존이 용이한 동결건조 형태.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 500–550 of human ABCC5 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C and avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide shares 91% identity with mouse and rat sequences.
- Specificity: ABCC5.
Target Information
ABCC5 (MRP5) is a member of the ATP-binding cassette (ABC) transporter superfamily, which mediates the transport of various molecules across cellular membranes.
This protein belongs to the MRP subfamily associated with multidrug resistance and functions in the cellular export of cyclic nucleotides.
It contributes to the degradation of phosphodiesterases and may play a role in the elimination of cyclic nucleotides.
ABCC5 confers resistance to thiopurine anticancer drugs (6-mercaptopurine and thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine.
It may be involved in resistance mechanisms in acute lymphoblastic leukemia and HIV-infected patients.
Alternative splicing has been observed, though the complete sequence and translation initiation site remain unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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