Thermo Fisher Scientific FOXP3 Polyclonal Antibody, DyLight 650

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody reacts weakly with human samples.

Target Information

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis.
FOXP3 is 381 amino acids long, expressed at high levels in CD25⁺ CD4⁺ regulatory T cells, low in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
It functions as a master regulatory gene and a specific marker of regulatory T cells.
Defects in FOXP3 cause the scurfy phenotype in mice and are associated with IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome) in humans.
In human breast and colon cancer cells, FOXP3 expression is regulated by p53 in response to DNA damage.
Transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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