Thermo Fisher Scientific Lamin A Monoclonal Antibody (133A2)
Lamin A 단백질을 검출하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 133A2). Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합. 인간, 마우스, 랫, 개, 소 시료에서 반응. 고순도 액상 형태로 1 mg/mL 농도 제공.
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Thermo Fisher Scientific Lamin A Monoclonal Antibody (133A2)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:200 | - |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | View 3 publications |
| Flow Cytometry (Flow) | 1:100–1:200 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 133A2 |
| Immunogen | Partially purified recombinant human lamin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_559889 |
Product Specific Information
MA1-06101 detects lamin A in human, mouse, rat, bovine, and canine samples.
It has been successfully used in immunocytochemistry, immunohistochemistry (paraffin), flow cytometry, and Western blotting procedures.
The immunogen used is partially purified recombinant human lamin A.
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane.
Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel 10, arising from the same gene by alternative splicing.
B-type lamins include lamin B1 and lamin B2, encoded by two distinct genes.
Mutations in A-type lamins can cause rare but dominant genetic disorders such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
Expression of A-type lamins is associated with cell differentiation and chromatin interaction, suggesting a role in regulating differential gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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