
Thermo Fisher Scientific Lamin A/C Monoclonal Antibody (131C3)
Lamin A/C 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 131C3). Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용 가능. Human, Mouse 등 여러 종에 반응하며 1 mg/mL 농도의 액상형 비접합 항체. 연구용으로만 사용.
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Thermo Fisher Scientific Lamin A/C Monoclonal Antibody (131C3)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:1,000 | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:200 | View 1 publication |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View 1 publication |
| Flow Cytometry (Flow) | 1:100–1:200 | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Hamster, Human, Mouse, Sheep, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 131C3 |
| Immunogen | Purified rat liver lamin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_559890 |
Product Specific Information
- MA1-06102 detects lamin A and C in human, mouse, rat, bovine, hamster, sheep, and canine samples.
- Successfully used in immunocytochemistry, immunohistochemistry, FACS, and Western blotting procedures.
- Immunogen: purified rat liver lamins.
- Reacts with an epitope located between residues 319–566 in lamin A and C.
Target Information
Lamins are intermediate filament proteins forming a matrix on the inner surface of the nuclear envelope.
Lamins A and C are alternatively spliced versions of the LMNA gene.
Mutations in LMNA are associated with various disorders such as:
- Emery-Dreifuss muscular dystrophy
- Dunnigan-type familial partial lipodystrophy (FPLD)
- Limb-girdle muscular dystrophy (LGMD1B)
- Dilated cardiomyopathy (CMD1A)
- Axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1)
- Mandibuloacral dysplasia (MAD)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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