Thermo Fisher Scientific Lamin A/C Monoclonal Antibody (131C3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:1,000

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Immunohistochemistry (Frozen) (IHC (F))

1:100-1:200

-

Immunocytochemistry (ICC/IF)

Assay-dependent

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Flow Cytometry (Flow)

1:100-1:200

-

Miscellaneous PubMed (Misc)

-

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Product Specifications

Species Reactivity

Bovine, Dog, Hamster, Human, Mouse, Sheep, Rat

Published species

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

131C3

Immunogen

Purified rat liver lamin. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Lamin A/C,uniProtId:P48679-1,ncbiNodeId:10114,antigenRange:1-665,antigenLength:665,antigenImageFileName:MA1-06102_Lamin_AC_P48679-1_House_mouse.svg,antigenImageFileNamePDP:MA1-06102_Lamin_AC_P48679-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

purified

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_559890

Product Specific Information

MA1-06102 detects lamin A and C in human, mouse, rat, bovine, hamster, sheep, and canine samples.

MA1-06102 has sucessfully been used in immunocytochemistry, immunohistochemistry, FACs and Western blotting procedures.

The MA1-06102 immunogen is purified rat liver lamins.

MA1-06102 reacts with an epitope located between residues 319-566 in lamin A and C.

Target Information

Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.