Thermo Fisher Scientific Phospho-Catenin alpha-1 (Tyr148) Polyclonal Antibody
Phospho-alpha1-Catenin (Tyr148) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 세포 접착 및 액틴 필라멘트 조절 연구에 유용. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:100
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-alpha1-Catenin (Tyr-148) synthetic peptide (coupled to KLH), corresponding to amino acid residues around tyrosine 148 in human alpha1-Catenin. Highly conserved in rat and mouse alpha1-Catenin, not conserved in alpha2 or alpha3-Catenin. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942890 |
Product Specific Information
This antibody was cross-adsorbed to unrelated phospho-tyrosine peptide before affinity purification using phospho-alpha1-Catenin (Tyr-148) peptide (without carrier). It detects a 102 kDa protein corresponding to the molecular mass of alpha1-Catenin on SDS-PAGE immunoblots of rat PC12 cells treated with pervanadate.
Target Information
Alpha1-Catenin associates with the cytoplasmic domain of various cadherins, forming complexes linked to the actin filament network—critical for cadherin-mediated cell adhesion. It interacts with both E- and N-cadherins. While originally thought to stably link cadherins to actin at adherens junctions, studies show CTNNA1 does not bind F-actin when in complex form, suggesting a dynamic linkage mechanism. The homodimeric form may regulate actin filament assembly and inhibit branching by competing with the Arp2/3 complex, playing a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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