Thermo Fisher Scientific PRDM16 Polyclonal Antibody
PRDM16 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로 연구용에 적합. PRDM16 관련 세포 분화 및 암 연구에 활용 가능.
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Thermo Fisher Scientific PRDM16 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1.0 µg/mL | View 18 publications |
| Immunohistochemistry (IHC) | 2 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the carboxy terminus of human PRDM16 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154178 |
Product Specific Information
PA5-20872 can be used with blocking peptide PEP-0986.
Target Information
PRDM16 is a zinc finger transcription factor containing an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and is specifically expressed in t(1;3)(p36,q21)-positive MDS/AML. The translocation leads to overexpression of a truncated protein lacking the PR domain, which may play a role in MDS and AML pathogenesis. PRDM16 acts as a Smad3 binding protein involved in orofacial development via TGF-beta signaling modulation and regulates cell fate between skeletal myoblasts and brown fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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