Thermo Fisher Scientific KCNK18 Polyclonal Antibody
KCNK18(TRESK) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. WB, IHC, ICC/IF에 사용 가능하며, 인간·마우스·랫트 반응성. 항원 친화 크로마토그래피로 정제, 액상 형태로 제공되며 단기 냉장·장기 냉동 보관 권장.
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Thermo Fisher Scientific KCNK18 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the center of human TRESK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152854 |
Product Specific Information
- Suggested positive control: Rat brain tissue lysate
- PA5-20873 can be used with blocking peptide PEP-0987
Target Information
TRESK (TWIK-related spinal cord K⁺ channel) is a two-pore domain potassium channel that induces outward rectification and functions as a background K⁺ channel. It is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes.
TRESK is activated by increased cytoplasmic calcium concentration through calcineurin, as well as by acetylcholine and histamine.
It has been suggested that TRESK is linked to acute and chronic pain via calcineurin activation. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target for treating T-cell originated immune dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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