OsmoTECH® HT Automated Micro-Osmometer

Optimize your high-throughput osmolality testing workflow

  • Automation-friendly 96-well plate-based format for high-throughput testing
  • Preserve sample with small testing volume
  • Powerful data integrity and management features for easy data tracking and compliance


96 Well Plate-Based Osmometer for High-Throughput Labs

The OsmoTECH HT Automated Micro-Osmometer, is the only plate-based micro-osmometer currently available to support the growing automation and high throughput needs in bioprocessing. Designed in a 96-well format this automation-friendly instrument ensures efficiency and acceleration of osmolality testing in early process development, formulation screening, and formulation development workflows.

Highlighted features
  • Automation-friendly 96-well plate-based format
  • Small sample volume requirement
  • Reliable and consistent performance
  • Robust data integrity
  • Flexible and secure data management
  • Easy to use

Built for your process development and drug formulation needs

High-throughput bioprocess development involves many complex workflows. Between the need to perform osmolality testing on large numbers of samples and monitor multiple additional parameters, optimizing your lab’s workflows is critical. Automation-friendly features support your high-throughput environment, streamlining efficiency and reducing hands-on operator time.

Upstream Manufacturing Applications

Clone Screening

Speed to market, boost cell longevity, increase yield and reduce production costs — Know more about your clones sooner and select the best clones earlier in the process.

Cell Line Development

Boost cell longevity and maximize cell productivity — Optimize osmolality when developing new feeds and additives in cell culture to increase cell longevity.

Formulation Development

Accelerate formulation development and stability testing — Integrate into automated workflows providing excipient concentrations and confirm the soluble content of formulations.

Product Features

Effortlessly run multiple samples

  • Plate-loading format allows samples to be robotically pipetted
  • 96-well plate
  • Load up to two plates for 192 tests

Automation-friendly workflows

  • Streamline efficiency
  • Reduce hands-on operator time
  • Seamless integration with automation workflows (Ambr®, Cedex®, and liquid handling automation systems)

Minimize testing downtime

  • Perform up to 1,000 tests before a consumables change is required
  • Uninterrupted sample testing overnight and weekends

Conserve vital samples

  • Only 40 µL sample volume needed for early process osmolality testing
  • 20 µL for STAT testing

User-friendly interface

  • Touchscreen interface
  • Step-by-step guides for tests
  • Easy access to test and consumable status

Assure accuracy

  • Seal plate with custom cover to prevent evaporation and ensure repeatable and reliable results

Flexible and secure data management

  • Save data to a network database, USB device or web server
  • Automate the process with bi-directional communication to eliminate transcription errors and save time
  • Easily integrate results into a data management system and batch records with OPC-UA

Automated self-cleaning

  • Automated sampling and fluid cleaning
  • Eliminate sample carryover and cross-contamination

Customizable templates

  • Develop and store templates
  • Reduce set-up time

Support compliance

  • 21 CFR part 11 compliant
  • Ease of implementation into a GMP environment

Backed by comprehensive support

  • Purchase instruments with peace of mind
  • Knowledgeable, experienced, and responsive support team
Sample type Aqueous-based solution
Sample volume per test 40 μL
Test time 140 seconds
Sample Capacity Multi plate
Resolution 1 mOsm/kg H2O
Range1 0-2000 mOsm/kg H2O
(AI standards and reference solutions)
Mean value ±3 mOsm/kg H2O from nominal value between 0 and 400 mOsm/kg H2O (1 SD)
Mean value ±1% from nominal value greater than 400 to 2000 mOsm/ kg H2O (1 SD)
Within-run Repeatability2
(AI Standards and Reference Solutions)
Standard deviation ≤3 mOsm/kg H2O between 0 and 400 mOsm/kg H2O
Coefficient of variation ≤1% greater than 400 to 2000 mOsm/kg H2O
Operating conditions Temperature: 18 °C to 35 °C (64 °F to 95 °F)
Humidity: 5 to 80% relative humidity (non-condensing)
Supported Languages English, Simplified Chinese, French, German, Italian, Japanese, Korean, Portuguese, Russian, Spanish, Turkish
Storage temperature -20 °C to +45 °C (-4 °F to +113 °F)
Electrical voltage 100 to 240 VAC (50/60 Hz)
Power consumption 60 Watts
Dimensions (D x W x H) 48.9 cm D x 62.87 cm W x 68.58 cm H (19.25” D X 24.75” W X 27 H”)
Net weight 59.7 kg (131.6 lbs.)
Shipping weight 111.9 kg (246.6 lbs.)
Warranty One-year limited warranty on workmanship and parts
  1. Advanced Instruments completes testing from 0 mOsm/kg sample to 2000 mOsm/kg sample during in-house linearity testing.
  2. Performance at reference conditions: 20 °C to 25 °C (68 °F to 77 °F); 30 to 60% relative humidity.

Osmometer Calibration Standards and Reference Solutions

SK-TECHHT OsmoTECH HT Convenience Kit ( Includes 3MA635 , 635910, 635934 , 635920, 3MA029, 3LA028, 202850)
3MA635 OsmoTECH HT Calibration and Verification Standard Set


635920 OsmoTECH HT 96 Well Plate Kit
635934 OsmoTECH HT System Fluid
635910 OsmoTECH HT Cleaning Reel
HT1000 OsmoTECH HT Micro-Sample Tubes, Pkg 1000
240821 Sampler Tips, 50/pkg


135022 Epson Dot Matrix Printer (sold-separately)
AN2TP5 Dot Matrix Printer Paper
700056 Barcode scanner

Clinitrol™ 290 Reference Solution

10 x 2 mL Ampules

View Product

Osmolality Linearity Set

0, 500, 900, 1500, 2000 mOsm/kg H2O 5x 2x 2 mL Ampules

View Product

Osmometer Calibration Standards

Available from 0-4000 mOsm/kg H2O 10 x 2 mL Ampules

View Product

Protinol™ Protein-Based Controls

Protinol 3-Level Osmometer Control 3x3x3 mL

View Product

###### All models support

Pharmacopeia testing guidelines

OsmoTECH® HT Automated Micro-Osmometer

OsmoTECH® PRO Multi-Sample Micro-Osmometer

OsmoTECH® XT Single-Sample Micro-Osmometer

OsmoTECH® Single-Sample Micro-Osmometer

Model 3250 Single-Sample Osmometer

Being discontinued Dec. 31, 2020
--- --- --- --- --- ---
Best for labs with daily sample processing needs of: >20/day >10/day 1-10/day 1-10/day 1-10/day
Sample volume 40 µL 30 µL 20 µL 20 µL 250 µL
Sample introduction 96 well plate Sample cup One-step direct One-step direct Sample cup
Operating range (mOsm/kg H2O) 0 - 2,000 mOsm/kg H2O 0 - 2,000 mOsm/kg H2O 0 – 4,000 mOsm/kg H2O 0 - 2,000 mOsm/kg H2O 0 - 4,000
Test time (seconds) 140 90 Less than 150 in low range, Less than 190 in high range 90 120
Multi-sample capacity
Automated cleaning between samples
Complex Matrices (High Concentrations, Sugars, & Proteins)
Integrated barcode scanner
Onboard Video Instructions
Multi-language touchscreen display
Supports 21 CFR Part 11 & EU Annex 11 compliance
Electronic Signature (Review & Approve)
Supports Pharmacopeia testing guidelines compliance
Username & Password Compatibility (With Active Directory)
Dot-matrix Printer
Network Connection
Network share
Automatic backup
Control device remotely via OPC-UA
Webserver for remote data viewing
Data Storage Capacity Unlimited Unlimited Unlimited Unlimited
Levels of users access 3 Levels 3 Levels 3 Levels 3 Levels
Data Format .csv & pdf .csv & pdf .csv & pdf .csv & pdf
Download Chart as a PDF

1. Sold separately
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