Advanced Instruments OsmoTECH HT Automated Micro-Osmometer
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OsmoTECH® HT Automated Micro-Osmometer
Optimize your high-throughput osmolality testing workflow
- Automation-friendly 96-well plate-based format for high-throughput testing
- Preserve sample with small testing volume
- Powerful data integrity and management features for easy data tracking and compliance
96 Well Plate-Based Osmometer for High-Throughput Labs
The OsmoTECH HT Automated Micro-Osmometer, is the only plate-based micro-osmometer currently available to support the growing automation and high throughput needs in bioprocessing. Designed in a 96-well format this automation-friendly instrument ensures efficiency and acceleration of osmolality testing in early process development, formulation screening, and formulation development workflows.
Highlighted features
- Automation-friendly 96-well plate-based format
- Small sample volume requirement
- Reliable and consistent performance
- Robust data integrity
- Flexible and secure data management
- Easy to use
Built for your process development and drug formulation needs
High-throughput bioprocess development involves many complex workflows. Between the need to perform osmolality testing on large numbers of samples and monitor multiple additional parameters, optimizing your lab’s workflows is critical. Automation-friendly features support your high-throughput environment, streamlining efficiency and reducing hands-on operator time.
Upstream Manufacturing Applications
Clone Screening
Speed to market, boost cell longevity, increase yield and reduce production costs — Know more about your clones sooner and select the best clones earlier in the process.
Cell Line Development
Boost cell longevity and maximize cell productivity — Optimize osmolality when developing new feeds and additives in cell culture to increase cell longevity.
Formulation Development
Accelerate formulation development and stability testing — Integrate into automated workflows providing excipient concentrations and confirm the soluble content of formulations.
Product Features
Effortlessly run multiple samples
- Plate-loading format allows samples to be robotically pipetted
- 96-well plate
- Load up to two plates for 192 tests
Automation-friendly workflows
- Streamline efficiency
- Reduce hands-on operator time
- Seamless integration with automation workflows (Ambr®, Cedex®, and liquid handling automation systems)
Minimize testing downtime
- Perform up to 1,000 tests before a consumables change is required
- Uninterrupted sample testing overnight and weekends
Conserve vital samples
- Only 40 µL sample volume needed for early process osmolality testing
- 20 µL for STAT testing
User-friendly interface
- Touchscreen interface
- Step-by-step guides for tests
- Easy access to test and consumable status
Assure accuracy
- Seal plate with custom cover to prevent evaporation and ensure repeatable and reliable results
Flexible and secure data management
- Save data to a network database, USB device or web server
- Automate the process with bi-directional communication to eliminate transcription errors and save time
- Easily integrate results into a data management system and batch records with OPC-UA
Automated self-cleaning
- Automated sampling and fluid cleaning
- Eliminate sample carryover and cross-contamination
Customizable templates
- Develop and store templates
- Reduce set-up time
Support compliance
- 21 CFR part 11 compliant
- Ease of implementation into a GMP environment
Backed by comprehensive support
- Purchase instruments with peace of mind
- Knowledgeable, experienced, and responsive support team
Sample type | Aqueous-based solution |
Sample volume per test | 40 μL |
Test time | 140 seconds |
Sample Capacity | Multi plate |
Resolution | 1 mOsm/kg H2O |
Range1 | 0-2000 mOsm/kg H2O |
Accuracy2 (AI standards and reference solutions) |
Mean value ±3 mOsm/kg H2O from nominal value between 0 and 400 mOsm/kg H2O (1 SD) Mean value ±1% from nominal value greater than 400 to 2000 mOsm/ kg H2O (1 SD) |
Within-run Repeatability2 (AI Standards and Reference Solutions) |
Standard deviation ≤3 mOsm/kg H2O between 0 and 400 mOsm/kg H2O Coefficient of variation ≤1% greater than 400 to 2000 mOsm/kg H2O |
Operating conditions | Temperature: 18 °C to 35 °C (64 °F to 95 °F) Humidity: 5 to 80% relative humidity (non-condensing) |
Supported Languages | English, Simplified Chinese, French, German, Italian, Japanese, Korean, Portuguese, Russian, Spanish, Turkish |
Storage temperature | -20 °C to +45 °C (-4 °F to +113 °F) |
Electrical voltage | 100 to 240 VAC (50/60 Hz) |
Power consumption | 60 Watts |
Dimensions (D x W x H) | 48.9 cm D x 62.87 cm W x 68.58 cm H (19.25” D X 24.75” W X 27 H”) |
Net weight | 59.7 kg (131.6 lbs.) |
Shipping weight | 111.9 kg (246.6 lbs.) |
Warranty | One-year limited warranty on workmanship and parts |
- Advanced Instruments completes testing from 0 mOsm/kg sample to 2000 mOsm/kg sample during in-house linearity testing.
- Performance at reference conditions: 20 °C to 25 °C (68 °F to 77 °F); 30 to 60% relative humidity.
Osmometer Calibration Standards and Reference Solutions
SK-TECHHT | OsmoTECH HT Convenience Kit ( Includes 3MA635 , 635910, 635934 , 635920, 3MA029, 3LA028, 202850) |
3MA635 | OsmoTECH HT Calibration and Verification Standard Set |
Supplies
635920 | OsmoTECH HT 96 Well Plate Kit |
635934 | OsmoTECH HT System Fluid |
635910 | OsmoTECH HT Cleaning Reel |
HT1000 | OsmoTECH HT Micro-Sample Tubes, Pkg 1000 |
240821 | Sampler Tips, 50/pkg |
Accessories
135022 | Epson Dot Matrix Printer (sold-separately) |
AN2TP5 | Dot Matrix Printer Paper |
700056 | Barcode scanner |
Clinitrol™ 290 Reference Solution
10 x 2 mL Ampules
0, 500, 900, 1500, 2000 mOsm/kg H2O 5x 2x 2 mL Ampules
Osmometer Calibration Standards
Available from 0-4000 mOsm/kg H2O 10 x 2 mL Ampules
Protinol™ Protein-Based Controls
Protinol 3-Level Osmometer Control 3x3x3 mL
###### All models support Pharmacopeia testing guidelines |
New! OsmoTECH® HT Automated Micro-Osmometer |
OsmoTECH® PRO Multi-Sample Micro-Osmometer |
OsmoTECH® XT Single-Sample Micro-Osmometer |
OsmoTECH® Single-Sample Micro-Osmometer |
Model 3250 Single-Sample Osmometer Being discontinued Dec. 31, 2020 |
--- | --- | --- | --- | --- | --- |
Best for labs with daily sample processing needs of: | >20/day | >10/day | 1-10/day | 1-10/day | 1-10/day |
Sample volume | 40 µL | 30 µL | 20 µL | 20 µL | 250 µL |
Sample introduction | 96 well plate | Sample cup | One-step direct | One-step direct | Sample cup |
Operating range (mOsm/kg H2O) | 0 - 2,000 mOsm/kg H2O | 0 - 2,000 mOsm/kg H2O | 0 – 4,000 mOsm/kg H2O | 0 - 2,000 mOsm/kg H2O | 0 - 4,000 |
Test time (seconds) | 140 | 90 | Less than 150 in low range, Less than 190 in high range | 90 | 120 |
Multi-sample capacity | |||||
Automated cleaning between samples | |||||
Complex Matrices (High Concentrations, Sugars, & Proteins) | |||||
Integrated barcode scanner | |||||
Onboard Video Instructions | |||||
Multi-language touchscreen display | |||||
Supports 21 CFR Part 11 & EU Annex 11 compliance | |||||
Electronic Signature (Review & Approve) | |||||
Supports Pharmacopeia testing guidelines compliance | |||||
Username & Password Compatibility (With Active Directory) | |||||
Dot-matrix Printer | |||||
Network Connection | |||||
Network share | |||||
Automatic backup | |||||
Control device remotely via OPC-UA | |||||
USB | |||||
Webserver for remote data viewing | |||||
Data Storage Capacity | Unlimited | Unlimited | Unlimited | Unlimited | |
Levels of users access | 3 Levels | 3 Levels | 3 Levels | 3 Levels | |
Data Format | .csv & pdf | .csv & pdf | .csv & pdf | .csv & pdf | |
Part # | OSMOTECHHT | OsmoTECHPRO | OsmoTECHXT | OsmoTECH | 3250 |
Download Chart as a PDF 1. Sold separately |
Learn More Request Pricing | Learn More Request Pricing | Learn More Request Pricing | Learn More Request Pricing | Learn More Request Pricing |
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