OsmoTECH® XT Single-Sample Micro-Osmometer


Best-in-class osmolality performance.

  • Intelligent freezing technology reliably and accurately tests a wide variety of samples including complex matrices
  • Small sample volume uses only 20 μLs for testing
  • Fully supports 21 CFR Part 11, GMP, and EU Annex 11 compliance

Best-in-class osmolality performance, designed with you in mind​.

OsmoTECH XT empowers labs with accurate and precise osmolality analysis for a wide range of liquid samples across bioprocessing and cell & gene therapy workflows.

Streamline your osmolality workflow with a user-friendly interface and ensure robust data integrity with compliance features to match any digital environment.

Highlighted features
  • Widest Range Osmolality Testing
  • Small Sample Size ​
  • Intelligent Freezing Technology
  • Intuitive Interface
  • 21 CFR Part 11, GMP, EU Annex 11 Compliance
  • Pharmacopeia Compliance

Confidence in your process and quality control

Osmolality testing with OsmoTECH XT ensures reliable and robust analysis providing you with confidence in the development of a quality therapeutic. The OsmoTECH XT unlocks the next generation of freezing point depression testing to determine the osmolality of even the most complex samples. Engineered in collaboration with scientists across bioprocessing workflows to address the unique user and data security pain points found throughout every stage of the bioprocessing workflow.

Industry Applications

In Biotech Labs

Maximize biologic yield, quality, and purity by optimizing and ensuring the quality and consistency of your buffers, media, product, excipients, and process parameters.

In Food & Beverage Labs

Boost efficiency, ensure product quality, and maintain process consistency with osmolality testing from formulation to release.

Product Features

Intelligent freezing technology

  • Only 20 uL sample volume with optimized cooling engine
  • Measure even the most complex samples with more accuracy and precision

Experience widest range of osmolality 0 - 4000 mOsm/kgH2O

  • Measure high concentrated solutions such as proteins and sugars
  • Remove dilutions

Supports compliance

  • 21 CFR part 11 / EU Annex 11
    • e-Signature
    • Three level user access
    • Password protection
    • And more
  • GMP environment
  • Pharmacopeia osmolality testing guidelines

Robust and flexible data management

  • Network share (pdf & csv)
  • Open Protocol Communication (OPC-UA)
  • LIS (TCP/IP) Communication
  • Bi-directional data management capability with OPC-UA to connect lab management (LIMS) and middleware software
  • Active directory
  • USB download
  • Optional dot-matrix printer

One-step direct sampling

  • Positive displacement sampler
  • Aspirate highly viscous sample types (hyaluronate, cryopreservatives, etc.)

Preserve your audit trail

  • Integrated barcode scanner for sample identification and reduced transcription errors
  • Automatic, manual, synchronous back up
  • Complete time-stamped record of usage, role, and actions requiring reason for settings changes
  • Ability to annotate test results via the handy comments field

Simple user interface

  • Large touchscreen

Optimized lab space

  • Integrated consumable shelf
  • Clean-room friendly consumables
Sample type Aqueous-based solution
Sample volume 20 ± 1 μL
Test time ≤150 seconds in low range; ≤190 seconds in high range
Sample Capacity Single sample
Resolution 1 mOsm/kg H2O
Range 0-4000 mOsm/kg H2O
Accuracy ±2 mOsm/kg H2O from nominal value between 0 and 400 mOsm/kg H2O (1 SD)

±0.5% from nominal value between 400 and less than 1500 mOsm/kg H2O (1 SD)

±1% from nominal value from 1500 to 4000 mOsm/kg H2O (1 SD)
Within-run Repeatability (AI Standards and Reference Solutions) Standard deviation ≤ 2 mOsm/kg H2O between 0 and 400 mOsm/kg H2O

Coefficient of variation ≤ 0.5% between 400 and less than 1500 mOsm/kg H2O

Coefficient of variation ≤ 1% from 1500 to 4000 mOsm/kg H2O
Supported Languages English, Simplified Chinese, French, German, Italian, Japanese, Korean, Russian, Spanish, Turkish
Storage temperature -20 °C to +45 °C (-4 °F to +113 °F)
Electrical voltage 100 to 240 VAC (50/60 Hz)
Power consumption 60 Watts
Dimensions (D x W x H) Not including test kit: 15″ x 14″ x 10″ (38 cm x 36 cm x 25 cm)

Including test kit: 15″ x 14″ x 11.5″ (38 cm x 36 cm x 38 cm)
Net weight 5.9 kg (12.9 lbs.)
Shipping weight 11.4 kg (25 lbs.)
Warranty One-year limited warranty on workmanship and parts
  1. Subject to change

Osmometer Calibration Standards and Reference Solutions

SK-TECHXT OsmoTECH XT Convenience Kit (Includes: XT100, 3LA051, 3MA029, 3LA151, 3LA301, 3LA028, 3MA000, 3MA400)
3MA000 0 mOsm/kg H2O Calibration Standard, 10×2 mL ampules
3MA029 Clinitrol™ 290 Reference Solution, 10×2 mL ampules
3LA051 500 mOsm/kg H2O Calibration Standard, 10×5 mL ampules
3LA151 1500 mOsm/kg H2O Calibration Standard, 10×5 mL ampules
3LA301 3000 mOsm/kg H2O Calibration Standard, 10×5 mL ampules
3MA400 4000 mOsm Calibration Standard, 10×2 mL Ampules
3LA028 Osmolality Linearity Set 100-2,000 mOsm 5x2x5 mL
3MA002 Osmolality Linearity Set, 100-2,000 mOsm 5x2x2 mL


XT100 Micro-Sample Test Kit: 1 box of 100 chamber cleaners, 100 sampler tips, 1 plunger wire
3M0828A Plunger Wire, 1 per order (Replaces 3M0828- Plunger Wires, set of 2. Please note: A plunger wire is included in every 133800, TECH250, and XT100 Micro-Sample Test Kit box.)
3M0825 Ease-Eject 20-Microliter Sampler
240821 Sampler Tips, 50/pkg


135022 Epson Dot Matrix Printer (sold-separately)
AN2TP5 Dot Matrix Printer Paper

Clinitrol™ 290 Reference Solution

10 x 2 mL Ampules

View Product

Osmometer Calibration Standards

Available from 0-4000 mOsm/kg H2O 10 x 2 mL Ampules

View Product

Osmolality Linearity Set

0, 500, 900, 1500, 2000 mOsm/kg H2O 5x 2x 2 mL Ampules

View Product

Protinol™ Protein-Based Controls

Protinol 3-Level Osmometer Control 3x3x3 mL

View Product

###### All models support

Pharmacopeia testing guidelines

OsmoTECH® HT Automated Micro-Osmometer

OsmoTECH® PRO Multi-Sample Micro-Osmometer

OsmoTECH® XT Single-Sample Micro-Osmometer

OsmoTECH® Single-Sample Micro-Osmometer

Model 3250 Single-Sample Osmometer

Being discontinued Dec. 31, 2020
--- --- --- --- --- ---
Best for labs with daily sample processing needs of: >20/day >10/day 1-10/day 1-10/day 1-10/day
Sample volume 40 µL 30 µL 20 µL 20 µL 250 µL
Sample introduction 96 well plate Sample cup One-step direct One-step direct Sample cup
Operating range (mOsm/kg H2O) 0 - 2,000 mOsm/kg H2O 0 - 2,000 mOsm/kg H2O 0 – 4,000 mOsm/kg H2O 0 - 2,000 mOsm/kg H2O 0 - 4,000
Test time (seconds) 140 90 Less than 150 in low range, Less than 190 in high range 90 120
Multi-sample capacity
Automated cleaning between samples
Complex Matrices (High Concentrations, Sugars, & Proteins)
Integrated barcode scanner
Onboard Video Instructions
Multi-language touchscreen display
Supports 21 CFR Part 11 & EU Annex 11 compliance
Electronic Signature (Review & Approve)
Supports Pharmacopeia testing guidelines compliance
Username & Password Compatibility (With Active Directory)
Dot-matrix Printer
Network Connection
Network share
Automatic backup
Control device remotely via OPC-UA
Webserver for remote data viewing
Data Storage Capacity Unlimited Unlimited Unlimited Unlimited
Levels of users access 3 Levels 3 Levels 3 Levels 3 Levels
Data Format .csv & pdf .csv & pdf .csv & pdf .csv & pdf
Download Chart as a PDF

1. Sold separately
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