OsmoTECH® XT Single-Sample Micro-Osmometer

Best-in-class osmolality performance.

• Intelligent freezing technology reliably and accurately tests a wide variety of samples including complex matrices
• Small sample volume uses only 20 μLs for testing
• Fully supports 21 CFR Part 11, GMP, and EU Annex 11 compliance

Best-in-class osmolality performance, designed with you in mind​.

OsmoTECH XT empowers labs with accurate and precise osmolality analysis for a wide range of liquid samples across bioprocessing and cell & gene therapy workflows.

Streamline your osmolality workflow with a user-friendly interface and ensure robust data integrity with compliance features to match any digital environment.

Highlighted features

• Widest Range Osmolality Testing
• Small Sample Size ​
• Intelligent Freezing Technology
• Intuitive Interface
• 21 CFR Part 11, GMP, EU Annex 11 Compliance
• Pharmacopeia Compliance

Confidence in your process and quality control

Osmolality testing with OsmoTECH XT ensures reliable and robust analysis providing you with confidence in the development of a quality therapeutic. The OsmoTECH XT unlocks the next generation of freezing point depression testing to determine the osmolality of even the most complex samples. Engineered in collaboration with scientists across bioprocessing workflows to address the unique user and data security pain points found throughout every stage of the bioprocessing workflow.

Industry Applications

In Biotech Labs

Maximize biologic yield, quality, and purity by optimizing and ensuring the quality and consistency of your buffers, media, product, excipients, and process parameters.

In Food & Beverage Labs

Boost efficiency, ensure product quality, and maintain process consistency with osmolality testing from formulation to release.

Product Features

Intelligent freezing technology

• Only 20 uL sample volume with optimized cooling engine
• Measure even the most complex samples with more accuracy and precision

Experience widest range of osmolality 0 - 4000 mOsm/kgH2O

• Measure high concentrated solutions such as proteins and sugars
• Remove dilutions

Supports compliance

• 21 CFR part 11 / EU Annex 11
  • e-Signature
  • Three level user access
  • Password protection
  • And more
• GMP environment
• Pharmacopeia osmolality testing guidelines

Robust and flexible data management

• Network share (pdf & csv)
• Open Protocol Communication (OPC-UA)
• LIS (TCP/IP) Communication
• Bi-directional data management capability with OPC-UA to connect lab management (LIMS) and middleware software
• Active directory
• USB download
• Optional dot-matrix printer

One-step direct sampling

• Positive displacement sampler
• Aspirate highly viscous sample types (hyaluronate, cryopreservatives, etc.)

Preserve your audit trail

• Integrated barcode scanner for sample identification and reduced transcription errors
• Automatic, manual, synchronous back up
• Complete time-stamped record of usage, role, and actions requiring reason for settings changes
• Ability to annotate test results via the handy comments field

Simple user interface

• Large touchscreen

Optimized lab space

• Integrated consumable shelf
• Clean-room friendly consumables

Sample type	Aqueous-based solution
Sample volume	20 ± 1 μL
Test time	≤150 seconds in low range; ≤190 seconds in high range
Sample Capacity	Single sample
Resolution	1 mOsm/kg H2O
Range	0-4000 mOsm/kg H2O
Accuracy	±2 mOsm/kg H2O from nominal value between 0 and 400 mOsm/kg H2O (1 SD) ±0.5% from nominal value between 400 and less than 1500 mOsm/kg H2O (1 SD) ±1% from nominal value from 1500 to 4000 mOsm/kg H2O (1 SD)
Within-run Repeatability (AI Standards and Reference Solutions)	Standard deviation ≤ 2 mOsm/kg H2O between 0 and 400 mOsm/kg H2O Coefficient of variation ≤ 0.5% between 400 and less than 1500 mOsm/kg H2O Coefficient of variation ≤ 1% from 1500 to 4000 mOsm/kg H2O
Supported Languages	English, Simplified Chinese, French, German, Italian, Japanese, Korean, Russian, Spanish, Turkish
Storage temperature	-20 °C to +45 °C (-4 °F to +113 °F)
Electrical voltage	100 to 240 VAC (50/60 Hz)
Power consumption	60 Watts
Dimensions (D x W x H)	Not including test kit: 15″ x 14″ x 10″ (38 cm x 36 cm x 25 cm) Including test kit: 15″ x 14″ x 11.5″ (38 cm x 36 cm x 38 cm)
Net weight	5.9 kg (12.9 lbs.)
Shipping weight	11.4 kg (25 lbs.)
Warranty	One-year limited warranty on workmanship and parts

1. Subject to change

Osmometer Calibration Standards and Reference Solutions

SK-TECHXT	OsmoTECH XT Convenience Kit (Includes: XT100, 3LA051, 3MA029, 3LA151, 3LA301, 3LA028, 3MA000, 3MA400)
3MA000	0 mOsm/kg H2O Calibration Standard, 10×2 mL ampules
3MA029	Clinitrol™ 290 Reference Solution, 10×2 mL ampules
3LA051	500 mOsm/kg H2O Calibration Standard, 10×5 mL ampules
3LA151	1500 mOsm/kg H2O Calibration Standard, 10×5 mL ampules
3LA301	3000 mOsm/kg H2O Calibration Standard, 10×5 mL ampules
3MA400	4000 mOsm Calibration Standard, 10×2 mL Ampules
3LA028	Osmolality Linearity Set 100-2,000 mOsm 5x2x5 mL
3MA002	Osmolality Linearity Set, 100-2,000 mOsm 5x2x2 mL

Supplies

XT100	Micro-Sample Test Kit: 1 box of 100 chamber cleaners, 100 sampler tips, 1 plunger wire
3M0828A	Plunger Wire, 1 per order (Replaces 3M0828- Plunger Wires, set of 2. Please note: A plunger wire is included in every 133800, TECH250, and XT100 Micro-Sample Test Kit box.)
3M0825	Ease-Eject 20-Microliter Sampler
240821	Sampler Tips, 50/pkg

Accessories

135022	Epson Dot Matrix Printer (sold-separately)
AN2TP5	Dot Matrix Printer Paper

Clinitrol™ 290 Reference Solution

10 x 2 mL Ampules

View Product

Osmometer Calibration Standards

Available from 0-4000 mOsm/kg H2O 10 x 2 mL Ampules

View Product

Osmolality Linearity Set

0, 500, 900, 1500, 2000 mOsm/kg H2O 5x 2x 2 mL Ampules

View Product

Protinol™ Protein-Based Controls

Protinol 3-Level Osmometer Control 3x3x3 mL

View Product

###### All models support Pharmacopeia testing guidelines	New! OsmoTECH® HT Automated Micro-Osmometer	OsmoTECH® PRO Multi-Sample Micro-Osmometer	OsmoTECH® XT Single-Sample Micro-Osmometer	OsmoTECH® Single-Sample Micro-Osmometer	Model 3250 Single-Sample Osmometer Being discontinued Dec. 31, 2020
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Best for labs with daily sample processing needs of:	>20/day	>10/day	1-10/day	1-10/day	1-10/day
Sample volume	40 µL	30 µL	20 µL	20 µL	250 µL
Sample introduction	96 well plate	Sample cup	One-step direct	One-step direct	Sample cup
Operating range (mOsm/kg H2O)	0 - 2,000 mOsm/kg H2O	0 - 2,000 mOsm/kg H2O	0 – 4,000 mOsm/kg H2O	0 - 2,000 mOsm/kg H2O	0 - 4,000
Test time (seconds)	140	90	Less than 150 in low range, Less than 190 in high range	90	120
Multi-sample capacity
Automated cleaning between samples
Complex Matrices (High Concentrations, Sugars, & Proteins)
Integrated barcode scanner
Onboard Video Instructions
Multi-language touchscreen display
Supports 21 CFR Part 11 & EU Annex 11 compliance
Electronic Signature (Review & Approve)
Supports Pharmacopeia testing guidelines compliance
Username & Password Compatibility (With Active Directory)
Dot-matrix Printer
Network Connection
Network share
Automatic backup
Control device remotely via OPC-UA
USB
Webserver for remote data viewing
Data Storage Capacity	Unlimited	Unlimited	Unlimited	Unlimited
Levels of users access	3 Levels	3 Levels	3 Levels	3 Levels
Data Format	.csv & pdf	.csv & pdf	.csv & pdf	.csv & pdf
Part #	OSMOTECHHT	OsmoTECHPRO	OsmoTECHXT	OsmoTECH	3250
Download Chart as a PDF 1. Sold separately	Learn More Request Pricing	Learn More Request Pricing	Learn More Request Pricing	Learn More Request Pricing	Learn More Request Pricing