Thermo Fisher Scientific TYW1 Polyclonal Antibody
TYW1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. 인간 및 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the carboxy terminus of human TYW1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152896 |
Product Specific Information
- Suggested positive control: Human lung tissue lysate
- PA5-21152 can be used with blocking peptide PEP-1266.
Target Information
TYW1 (also known as TYW1A, RSAFD1, or YPL207W) is a 732 amino acid protein with a flavodoxin-like domain involved in the wybutosine-tRNA (Phe) biosynthesis pathway.
Wybutosine (yW) is a hypermodified guanosine at the 3′ position adjacent to the anticodon of phenylalanine tRNA, stabilizing codon-anticodon interactions during ribosomal decoding.
TYW1 participates in multistep enzymatic reactions that ensure correct translation by stabilizing codon-anticodon base-pairing.
It binds a 4Fe-4S cluster and is located on human chromosome 7.
Defects in chromosome 7 genes are associated with conditions such as Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome, suggesting TYW1 may play a role in these disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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