Thermo Fisher Scientific KAL1 Polyclonal Antibody
KAL1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. MCF7 cell lysate를 양성 대조군으로 권장합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the center of human Anosmin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156595 |
Product Specific Information
- A suggested positive control is MCF7 cell lysate.
- PA5-21149 can be used with blocking peptide PEP-1263.
Target Information
KAL1 (Anosmin-1) is an extracellular matrix-associated glycosylated protein linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell due to abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron.
Anosmin-1 directly binds FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 modulates FGFR1 signaling and has opposing effects on the formation and activation of the FGF2–FGFR1–heparin complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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